PTPRN2 Validated Chimera RNAi
产品名称： PTPRN2 Validated Chimera RNAi
英文名称： PTPRN2 Validated Chimera RNAi
产品编号： H00005799-R01V
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
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- Specification
- Product Description:
- Homo sapiens protein tyrosine phosphatase, receptor type, N polypeptide 2 (PTPRN2), transcript variant 3, mRNA.
- Reactivity:
- Human
- Storage Instruction:
- Store at -20°C, do not exceed 4 - 5 freeze-thaw cycles to ensure product integrity.
- Supplied Product:
- DEPC water
- Target Refseq:
- NM_002847
- Note:
- Position of the Chimera RNAi.
-
- Publication Reference
- 1.
- dsCheck: highly sensitive off-target search software for double-stranded RNA-mediated RNA interference.
Naito Y, Yamada T, Matsumiya T, Ui-Tei K, Saigo K, Morishita S.Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W589-91.
- 2.
- Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect.
Ui-Tei K, Naito Y, Zenno S, Nishi K, Yamato K, Takahashi F, Juni A, Saigo K.Nucleic Acids Res. 2008 Apr;36(7):2136-51. Epub 2008 Feb 11.
- 3.
- Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference.
Ui-Tei K, Naito Y, Takahashi F, Haraguchi T, Ohki-Hamazaki H, Juni A, Ueda R, Saigo K.Nucleic Acids Res. 2004 Feb 9;32(3):936-48. Print 2004.
- 4.
- siDirect: highly effective, target-specific siRNA design software for mammalian RNA interference.
Naito Y, Yamada T, Ui-Tei K, Morishita S, Saigo K.Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W124-9.
- Applications
- RNAi Knockdown (Antibody validated)
- Western blot analysis of PTPRN2 over-expressed 293 cell line, cotransfected with PTPRN2 Validated Chimera RNAi ( Cat # H00005799-R01V ) (Lane 2) or non-transfected control (Lane 1). Blot probed with PTPRN2 monoclonal antibody (M08), clone 7F8 (Cat # H00005799-M08 ). GAPDH ( 36.1 kDa ) used as specificity and loading control.
- Protocol Download
- Entrez GeneID:
- 5799
- Gene Name:
- PTPRN2
- Gene Alias:
- IA-2beta,IAR,ICAAR,PTPRP
- Gene Description:
- protein tyrosine phosphatase, receptor type, N polypeptide 2
- Omim ID:
- 601698
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. The catalytic domain of this PTP is most closely related to PTPRN/IA-2beta. This PTP and PTPRN are both found to be major autoantigens associated with insulin-dependent diabetes mellitus. Three alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq
- Other Designations:
- IAR/receptor-like protein-tyrosine phosphatase,phogrin,protein tyrosine phosphatase receptor pi,tyrosine phosphatase IA-2 beta
- Gene Pathway
- Related Disease
- Breast cancer
- Breast Neoplasms
- Cardiovascular Diseases
- Cerebral Hemorrhage
- Chromosome Deletion
- Chronic Disease
- Diabetes Mellitus, Type 2
- Edema
- Genetic Predisposition to Disease
- Hypertension
- Intracranial Hemorrhages
- Kidney Diseases
- Kidney Failure, Chronic
- Stroke
- Subarachnoid Hemorrhage
- Tobacco Use Disorder