FITC标记的受体活性修饰蛋白1抗体
产品名称： FITC标记的受体活性修饰蛋白1抗体
英文名称： Anti-RAMP1/FITC
产品编号： HZ-20214R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-RAMP1/FITC Conjugated antibody
FITC标记的受体活性修饰蛋白1抗体
| 英文名称 | Anti-RAMP1/FITC |
| 中文名称 | FITC标记的受体活性修饰蛋白1抗体 |
| 别 名 | calcitonin receptor like receptor activity modifying protein 1; RAMP 1; RAMP-1; CRLR activity modifying protein 1; receptor (G protein coupled) activity modifying protein 1; receptor activity modifying protein 1; Receptor activity modifying protein 1; RAMP1_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞膜受体 细胞表面分子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 14kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The protein encoded by this gene is a member of the RAMP family of single transmembrane domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin receptor like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin gene related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP1) protein, CRLR functions as a CGRP receptor. The RAMP1 protein is involved in the terminal glycosylation, maturation, and presentation of the CGRP receptor to the cell surface. Function: Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for calcitonin-gene-related peptide (CGRP) together with CALCRL. Subunit: Heterodimer of CALCRL and RAMP1. Subcellular Location: Membrane; Single-pass type I membrane protein. Tissue Specificity: Expressed in many tissues including the uterus, bladder, brain, pancreas and gastro-intestinal tract. Similarity: Belongs to the RAMP family. Database links: Entrez Gene: 10267 Human Entrez Gene: 51801 Mouse Entrez Gene: 58965 Rat Omim: 605153 Human SwissProt: O60894 Human SwissProt: Q9WTJ5 Mouse SwissProt: Q9JJ74 Rat Unigene: 471783 Human Unigene: 3272 Mouse Unigene: 12265 Rat
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
该基因编码的蛋白是单跨膜结构域蛋白RAMP家族的成员，称为受体（降钙素）活性修饰蛋白（RAMP）。斜坡是I型跨膜蛋白，胞外N端和胞质C端。斜坡需要将降钙素受体样受体（CRLR）转运到质膜上。CRLR是具有七个跨膜结构域的受体，根据RAMP家族的哪些成员被表达，它可以作为降钙素基因相关肽（CGRP）受体或肾上腺髓质素受体。在存在这种（RAMP1）蛋白的情况下，CRLR起CGRP受体的作用。RAMP1蛋白参与CGRP受体的糖基化、成熟和向细胞表面的递呈。